Endocrine Abstracts

Aim: To know if Tg levels after treatment (total thyroidectomy and radioiodine ablation) in the DTC can predict their prognosis in the long term.Material and methods: Basal Tg and Tg after rh-TSH were measured in 229 patients with DTC without any evidence of residual tumour (negative neck ultrasonography) after treatment. The group was followed until tumour recurrence or, if recurrence was not found, a minimum of 12 month (mean ± SD =63±37 mont...

Introduction and objective: Clinically nonfunctional pituitary adenomas are relatively an uncommon disease. The aim of this work is to describe the clinical characteristics and to review the results of transsphenoidal surgery (TS) of pituitary adenomas in a reference centre.Methods: A retrospective study (1995–2014) of 66 patients (50% men) diagnosed with pituitary adenomas by a magnetic resonance imaging (MRI) was conducted. demographic, clinical, ...

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...

Introduction and objectives: The strategies for therapy of metastatic medullary thyroid carcinoma (MTC) are limited. Although Tyrosine kinase inhibitors (TKI) seem to be the first-line treatment, we want to explore other possibilities. Metaiodobenzylguanidine (MIBG) is a guanethidine derivative, structurally similar to norepinephrine. It was developed as an imaging agent with 123I radiolabeling. MIBG localizes neuroendocrine tumors including MTC. We are investigatin...

Introduction: Thyroid nodule is a frequent condition, being diagnosed in up to 70% of subjects who had undergone thyroid ultrasound. Around 90-95% of them became being benign and, if the do not cause compressive symptoms or esthetical problems, they do not need specific therapy, only clinical follow up. Traditionally, thyroidectomy has been the main therapeutic option in these cases. Radiofrequency and ethanol ablations are recently introduced non-invasive therapies that permi...

Introduction: Active hypercortisolism of Cushing syndrome (CS) determines major changes in the plasticity and function of metabolic key target tissues as the adipose tissue (AT). Persistence of target tissue altered metabolic memory after the cure/remission of Cushing syndrome is still at debate as clinical observational studies are limited due to confounder factors both in endogenous as exogenous CS. We postulate that after remission of hypercortisolism, adipose tissue (AT) p...

Aim: To determine, in type 1 diabetes mellitus (T1DM) patients, if there is any relationship between the age at onset and the number of HLA risk alleles for T1DM (DRB1*03 and DRB1*04).Methods: Retrospective study. We selected patients with T1DM diagnosis (pancreatic autoimmunity and insulin-dependent diabetes) and age at onset >15 years, identifying 275 subjects (59.6% men and 40.4% women), with a median age at onset of 31 years (interquartile range ...